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Two steps in the metabolism of Hcy to glutathione, the master antioxidant, require B6 (see Figure 4 )

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Reactive astrogliosis plays essential roles in both attracting and containing neuroinflammation, and is critical for wound closure, fibrotic scar formation, erecting glia limitans barrier delineating the damaged tissue and supporting postlesional regeneration and plasticity

GSSG is composed of two reduced GSH molecules linked by a disulfide bond