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To our surprise, we discovered that Axin and GSK3 bind to the same region in the LRP6 ctail – Axin with low and GSK3 with barely measurable affinity – yet their docking at LRP6 in vivo requires their cooperation as it depends on their mutual binding to each other
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Likewise, this approach may contrast with therapeutic tactics for fistulas, which depend on their location and severity of occurrence (Orangio, 2010
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