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The induction of iNOS and subsequent production of NO inhibits mitochondrial oxidative phosphorylation (OxPhos) ( Figure 1 M2 macrophage polarization is driven by IL-4 and IL-13 signals through a heterodimeric receptor complex composed of the IL-4 receptor alpha chain (IL-4Rα) and the IL-13 receptor alpha 1 chain (IL-13Rα1) ( Figure 1B )