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The estrogen transdermal patch shortage—driven by a convergence of surging demand, limited manufacturers, tariff pressures on overseas production, and the ripple effects of Bayer’s 2023 discontinuation of its Climara patch—has created a real-time access crisis for women on stable HRT regimens

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Gastrointestinal Histology Intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and co-workers [62] on a scale from 0 to 5 (normal to severe) in 3 categories (mucosal injury, inflammation, hyperemia/hemorrhage) for a total score of 0 to 15 as described by Lane and co-workers [63]