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[3] [18] Individuals with significant myocardial disease such as AV block should avoid receiving parenteral magnesium as much as possible as this could lead to a worsening of this condition
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It does so through an epigenetic mechanism, where FGF15/19 interacts with its target nuclear receptors, such as small heterodimer partner (SHP), which then recruits DNA methyltransferase-3a (DNMT3a) to the lipogenic gene loci, including FASN
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