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IL-10 exerts its anti-inflammatory effect by inhibiting the expression of several pro-inflammatory cytokines, metalloproteinases such as MMP-9, COX2 and several apoptosis inhibitors such as caspase-3 (150, 154)
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This endothelial dysfunction contributes to the onset and advancement of diabetic vascular complications, such as coronary artery disease (macrovascular) and retinopathy (microvascular) [39]
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