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LXR is a ligand-activated nuclear receptor, and the expression of SREBP-1c and ChREBP is regulated by LXR, which controls the expression of genes involved in glycolysis and lipid synthesis, thereby playing a crucial role in the transcriptional control of lipid metabolism (Wang and Tontonoz, 2018)

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Comparison of the efficacy and liver function with different doses of S-adenosylmethionine combined with ursodeoxycholic acid for cholestatic liver disease