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Studies show that patients with AD exhibit reduced vitamin E levels in plasma, serum and cerebrospinal fluid, and those receiving vitamin E supplementation experience slower cognitive decline and decreased oxidative stress compared with placebo-treated individuals (101,108)
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Cleavable linkers – enzymatic linkers Cathepsin B substrate linker The mechanism of such linker cleavage is that after the ADC is internalized by endocytosis and transport to the lysosome, cathepsin B selectively cleaves the linker, and the payload is released from the ADC in a traceless manner, consisting mainly of dipeptides Linkers and Tetrapeptide Linkers
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