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With regard to dietary supplements , patients should be aware of the following: Herbal supplements with possible hypoglycaemic properties — such as berberine, bitter melon, or fenugreek — are sometimes cited as potentially enhancing blood glucose-lowering effects, though the clinical evidence for these interactions is limited and variable

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The pathology of MS lesions is heterogeneous (Lucchinetti et al., 2000) and several patterns suggesting predominant immune-mediated inflammation (pattern I and II) and primary oligodendrogliopathy (pattern III and IV) have been described (Lucchinetti et al., 1996, 2000)