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For use as a reducing agent, GSH, TCEP, MPD, or 2-ME was added (to 2 mM) in place of DTT

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Silencing TfR1 not only reduces chondrocytic iron content and oxidative stress but also promotes mitophagy and inhibits the mtDNA/cGAS/STING inflammatory axis, thereby breaking the cycle between ferroptosis and immune activation

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