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In humans, methylcobalamin functions in the folate-dependent methylation of homocysteine to methionine (Figure 22b.2) whereas 5'‑deoxyadenosyl-cobalamin plays a major part in the conversion of L‑methylmalonyl-coenzyme A to succinyl-coenzyme A in an isomerization reaction

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A March 2026 community synthesis noted a divided user base: some reporting consistent benefit, others reporting none

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