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It was shown that obesity-induced hypoxia increases the expression of miR-128, which then negatively affects INSR mRNA and protein expression levels in adipose tissue of both obese patients and high-fat diet-fed mice, correlating with the decrease in INSR expression
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The study highlights GHRP-2’s distinct mechanisms of action in treating obesity, including targeted fat reduction and appetite control, by contrasting it with other peptides, including AOD-9604, Tesamorelin, and Tesofensine
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