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MPs are released by various cell types and are involved in many physiological functions such as inflammation, homeostasis, coagulation, chemotherapeutic drug resistance and metastasis [2, 4, 34, 49, 50, 51–55]

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Accordingly, in an aqueous solution, glutathione can exist in four different macroscopic protonation states: where L 3− is the fully deprotonated, H 4 L + is the fully protonated GSH molecule