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This helps to improve the therapeutic efficacy and safety of drugs, reduce the risk of adverse reactions and treatment failure caused by differences in drug quality

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As reported, NLRP3 inflammasome activation plays a key role in defence against pathogens, and the mitochondria-related E3 ligase MARCH5 can interact with the NACHT domain of NLRP3 inflammasomes to mediate inflammasome activation (69)