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Irrespective of its mechanism of action, cuprizone is a widely utilised and validated toxin for modelling CNS demyelination that is not directly associated with peripheral autoimmunity 20

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In diet‑induced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF‑α and IL‑6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver