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7) Off-label : Treatment of & dissecting aortic aneurysm To produce controlled hypotension in neurosurgery to reduce bleeding in the operative field, and in patients undergoing electroconvulsive therapy Low dose mecamylamine may be of potential use in blocking the physiological effects of nicotine in patients under treatment for smoking cessation, as well as several other neuropsychiatric disorders (Shytle et al, 2002