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Ascorbic acid (vitamin C) is a reducing agent that binds to ARE, inhibits Nrf2 translocation to DNA, and decreases the levels of g-GCSl mRNA and GSH

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This might occur in a very short time with the major vessel occlusion [19,24,27,29], artery [19] or vein [24], or artery and vein [29], peripherally and centrally, and trapped large blood volume [19,24,29]