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Clinical Diagnosis of Lyme Disease Physical Exam and history Testing – may not get a positive for several weeks after bite Extended Western Blot Co-infections (Babesia, Bartonella, Ehrlichia, Anaplasma) CD57 PCR Inflammatory and Immune markers (ANA, ESR, hsCRP) Metabolic Markers Mitochondrial markers Other Infections (mycoplasma, viruses, strep, yeast) Intracellular infection Neuropsych testing SPECT & MRI with NeuroQuant – can see decreased perfusion in frontal and hippocampal areas Keep a checklist of symptoms The diagnosis of Lyme disease is a clinical diagnosis