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425,426 Systemic treatment for TNBC TNBC represents a highly heterogeneous group of tumors, and the therapeutic efficacy of traditional chemotherapy appears to have reached a plateau

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It is likely that some steps of the biotransformation of arsenic that involve the formation of glutathione-bound species can occur also involving individual cysteine thiol groups or pairs of vicinal thiol groups in proteins, such as the catalytically essential thiol groups of enzymes and the regulatory elements of effector proteins that can be modulated by reversible glutathionylation (see further)