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GPx3 can inhibit the activation of NF-κB through the Erk pathway, leading to the suppression of the cell-cycle proteins B1 and G2/M and the inhibition of EMT by downregulating the Erk-NF-κB-SIP1 signaling axis [126,142]

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BCa cells were cultured into a 6-well plate within 2 ml medium to 60 % confluence