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However, formation of glial scar via the accumulation of reactive astrocytes is a major obstacle to axonal regeneration by neurons after injuries (Zhang and De Koninck, 2006

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In the study by Mehta et al (Mehta A), children with congenital isolated GH deficiency demonstrated growth retardation as already at 6 months of age (−2·6 ± 1·0 SD and −2·2 ± 1·3 SD in weight and length, respectively) prior to starting treatment