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Some electrophilic drugs or toxins, for example, organoarsenites (As 3+ ) or organomercurial compounds, are glutathionylated yet also covalently bind with high affinity to Cys or Sec residues of GSR, TRXR1, and other critical enzymes, thereby irreversibly disrupting activity of these enzymes (104)

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Chronic (20 days) adolescent but not adult daily injection of CB (1) receptor agonist led to anxiety and depression-like behavior in the forced swim and sucrose preference test in rats

glutathione is an ally in healthy aging