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Larger randomized clinical trials of vitamin B 12 supplementation and analysis of markers such as total vitamin B 12 , holotranscobalamin, total homocysteine and methylmalonic acid, total folic acid, and, if possible, polymorphisms and methylation of genes need to be conducted with people with and without COVID-19 or who have had COVID-19 to facilitate the proper vitamin B 12 form to be administered in individual treatment