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IRAK4 oligomerizes through MyD88 to form the “Myddosome” complex, a central platform for IL-1R/TLR signaling, and phosphorylated IRAK4 activates downstream IRAK1, which together promote activation of the TRAF6/NF-κB pathway

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doi: 10.3390/toxins13030208 86 LiuMZhangCXuXZhaoXHanZLiuDet al