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Science 281 : 998–1001 Yamazaki S, Muta T, Takeshige K (2001) A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei

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That is to say that, over time, the concentration of GHB in the system decreases below the threshold for significant GABA B receptor activation and activates predominantly the GHB receptor, leading to wakefulness