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Abbreviations aCSF artificial cerebrospinal fluid AMPA α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid AngIV angiotensin IV (VYIHPF) ANOVA analysis of variance AT 4 angiotensin IV receptor subtype dihexa N -hexanoic-YI-(6) aminohexanoic amide DIV day(s) in vitro HEK-293 human embryonic kidney 293 cell HGF hepatocyte growth factor Hinge KDYIRN IRAP insulin-regulated membrane aminopeptidase MDCK Madin-Darby canine kidney cells mEPSC miniature excitatory postsynaptic current mRFP monomeric red fluorescent protein norleual Nle-YL-Ψ(CH 2 -NH 2 )-HPF PBS phosphate-buffered saline shRNA short hairpin RNA α -VGLUT1 vesicular glutamate transporter 1 Authorship Contributions Participated in research design: Benoist, Kawas, Harding, Wayman, Wright, Appleyard

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