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In addition, thromboembolic events both in association with, and separate from OHSS have been reported in women treated with gonadotropins, including GONAL-f

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Overall, multiple mechanisms including inflammation and reduced FA re-esterification likely explain the impaired buffering capacity in adipocytes during obesity that leads to the spillover of FAs, buildup of toxic lipid metabolites and allosteric regulators that suppress insulin action and increased hepatic glucose output, respectively (Figure 5)