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Crucially, NNMT is also associated with the phosphorylation status of kinases in the PI3K–Akt and MAPK–ERK pathways ( NNMT promoter and regulating its expression ( BRCA1 and CDK12 depletion contribute to mitochondrial respiration defects and decreased ATP levels due to the reduced mitochondrial DNA copy number rather than mitochondrial number, which suggest that they stem from decreased flux through electron transport complexes rather than a decrease in mitochondria (66)
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