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In rats, daily application of 1% w / w BCP emulgel improved closure and remodeling, with up-regulation of laminin-γ2, desmoglein-3, and collagen, reduced pro-inflammatory cytokines (TNF-α, IFN-γ, IL-1β, IL-6), increased IL-10, and antioxidant activity (elevated glutathione peroxidase, GPx), without hepatic or renal toxicity compared with comparators [32]

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indica fruit pulp extract was well-tolerated at doses up to 3,000 mg/kg, with no observed changes in gross behavior, signs of toxicity, or mortality (535)

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