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Targeted protein degradation technology for the treatment of AD Protein hydrolysis-targeted chimeras (PROTACs) are a UPS-based targeted protein degradation technology, the core of which is designed as a bifunctional small-molecule chimera consisting of a target protein ligand (which specifically binds to the target protein, POI), E3 ubiquitin ligase ligand (which recruits a specific E3 ubiquitin ligase), and a linker (which bridges the two ligands mentioned above via a chemical chain to form a ternary complex)

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doi: 10.3390/foods10102324 202