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GPX1 (-,-) mice expressed unchanged levels of GPX4, GPX3 and GPX2, which may particularly substitute for the GPX1 deficiency (50)

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As the implanted tumour cells lack p53 expression (ID8 Trp53 −/− ), and p21 is a p53-dependent gene, we wanted to confirm that (a subset of) the p21-positive cells were tumour derived