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NF-κb-Mediated Neuroinflammation in Parkinson’s Disease and Potential Therapeutic Effect of Polyphenols

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5.2 PTSD as a result of adverse childhood experiences (ACE) Adverse childhood experiences (ACE), as demonstrated in Figure 5, can disrupt neurodevelopment causing social, emotional, and cognitive impairment in children that lead to the adoption of health-risk behavior leading to adulthood illnesses including cardiovascular diseases, sleep disorders, obesity, and the like [79]