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Although extremely rare, hydroxocobalamin injections can also cause serious side effects such as a major allergic reaction or irregular heartbeats (palpitations)
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In a prospective study of 1,134 women receiving chemotherapy for breast cancer, antioxidant supplement use during treatment was associated with a 41% higher risk of recurrence (adjusted HR 1.41), supporting current recommendations to avoid self-prescribing antioxidant supplements during chemotherapy (Ambrosone et al., 2020)
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