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The 2022 Dimet-Wiley paper in Scientific Reports characterised NNMT inhibition combined with reduced-calorie diet in diet-induced-obesity mouse model systems (PMID 35013352)
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The clinical manifestations and severity of these diseases are conditioned by changes in the epithelial integrity (including epithelial junction and intestinal permeability), proinflammatory immune responses, reorganization of intestinal vasculature, and intestinal motility
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